Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  ICAHN CARL C ET AL
 2. Date of Event Requiring Statement (Month/Day/Year)
07/27/2005		 3. Issuer Name and Ticker or Trading Symbol
ADVENTRX PHARMACEUTICALS INC [ANX]
(Last)
(First)
(Middle)
C/O ICAHN ASSOCIATES CORP, 767 5TH AVE #4700		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

NEW YORK, NY 10153		 6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 4,324,324
I
Please see explanation below (1) (2) (3) (4) (5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Warrants to acquire shares of Common Stock 01/27/2006 07/27/2012 Common Stock 4,324,324 $ 2.26 I Please see explanation below (1) (6) (7) (8) (9)

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
ICAHN CARL C ET AL
C/O ICAHN ASSOCIATES CORP
767 5TH AVE #4700
NEW YORK, NY 10153		     X    
Hopper Investments LLC
100 SOUTH BEDFORD ROAD
MT KISCO, NY 10549		     X    
BARBERRY CORP /NY/
100 SOUTH BEDFORD RD
MT KISCO, NY 10549		     X    
HIGH RIVER LIMITED PARTNERSHIP /NY/
100 SOUTH BEDFORD RD
MT KISCO, NY 10549		     X    
Icahn Partners Master Fund LP
C/O WALKERS SPV LIMITED, P.O. BOX 908GT
87 MARY STREET
GEORGE TOWN, GC E9 E9		     X    
Icahn Offshore LP
100 SOUTH BEDFORD ROAD
MT. KISCO, NY 10549		     X    
Icahn Onshore LP
100 SOUTH BEDFORD ROAD
MT. KISCO, NY 10549		     X    
Icahn Partners L P
767 5TH AVE 47TH FL
NEW YORK, NY 10151		     X    
CCI Onshore Corp.
100 SOUTH BEDFORD ROAD
MT KISCO, NY 10549		     X    
CCI Offshore Corp.
100 SOUTH BEDFORD ROAD
MT KISCO, NY 10549		     X    

Signatures

/s/ Carl C. Icahn 08/05/2005
**Signature of Reporting Person Date
/s/ CCI Onshore Corp. 08/05/2005
**Signature of Reporting Person Date
/s/ Icahn Onshore LP 08/05/2005
**Signature of Reporting Person Date
/s/ Icahn Partners LP 08/05/2005
**Signature of Reporting Person Date
/s/ CCI Offshore LP 08/05/2005
**Signature of Reporting Person Date
/s/ Icahn Offshore LP 08/05/2005
**Signature of Reporting Person Date
/s/ Icahn Partners Master Fund LP 08/05/2005
**Signature of Reporting Person Date
/s/ High River Limited Partnership 08/05/2005
**Signature of Reporting Person Date
/s/ Barberry Corp. 08/05/2005
**Signature of Reporting Person Date
/s/ Hopper Investments LLC 08/05/2005
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Barberry Corp. is the sole member of Hopper Investments LLC, which is the general partner of High River Limited Partnership. CCI Offshore Corp. is the general partner of Icahn Offshore LP, which is the general partner of Icahn Partners Master Fund LP. CCI Onshore Corp. is the general partner of Icahn Onshore LP, which is the general partner of Icahn Partners LP. Each of Barberry Corp., CCI Offshore Corp. and CCI Onshore Corp. is 100 percent owned by Carl C. Icahn. As such, Mr. Icahn is in a position directly and indirectly to determine the investment and voting decisions made by all of the foregoing entities.
(2) High River Limited Partnership owns 864,865 Shares. Icahn Partners Master Fund LP owns 1,798,919 Shares. Icahn Partners LP owns 1,660,540 Shares.
(3) Each of Hopper Investments LLC, Barberry Corp.and Mr. Icahn, by virtue of their relationships to High River Limited Partnership may be deemed to beneficially own (as that term is defined in Rule 13d-3 under the Act) the Shares which High River Limited Partnership owns, but each of them disclaims beneficial ownership of such Shares for all other purposes.
(4) Each of Icahn Offshore LP, CCI Offshore Corp. and Mr. Icahn by virtue of their relationships to Icahn Master Fund LP may be deemed to beneficially own (as that term is defined in Rule 13d-3 under the Act) the Shares which Icahn Partners Master Fund LP owns, but each of them disclaims beneficial ownership of such Shares for all other purposes.
(5) Each of Icahn Onshore LP, CCI Onshore Corp. and Mr. Icahn, by virtue of their relationships to Icahn Partners LP may be deemed to beneficially own (as that term is defined in Rule 13d-3 under the Act) the Shares which Icahn Partners LP owns, but each of them disclaims beneficial ownership of such Shares for all other purposes.
(6) High River Limited Partnership owns 864,865 Warrants. Icahn Partners Master Fund LP owns 1,798,919 Warrants. Icahn Partners LP owns 1,660,540 Warrants.
(7) Each of Hopper Investments LLC, Barberry Corp.and Mr. Icahn, by virtue of their relationships to High River Limited Partnership may be deemed to beneficially own (as that term is defined in Rule 13d-3 under the Act) the Warrants which High River Limited Partnership owns, but each of them disclaims beneficial ownership of such Warrants for all other purposes.
(8) Each of Icahn Offshore LP, CCI Offshore Corp. and Mr. Icahn by virtue of their relationships to Icahn Master Fund LP may be deemd to beneficially own (as that term is defined in Rule 13d-3 under the Act) the Warrants which Icahn Partners Master Fund LP owns, but each of them disclaims beneficial ownership of such Warrants for all other purposes.
(9) Each of Icahn Onshore LP, CCI Onshore Corp. and Mr. Icahn, by virtue of their relationships to Icahn Partners LP may be deemed to beneficially own (as that term is defined in Rule 13d-3 under the Act) the Warrants which Icahn Partners LP owns, but each of them disclaims beneficial ownership of such Warrants for all other purposes.

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