SCHEDULE 13G

Under the Securities Exchange Act of 1934
(Amendment No.     )*

(Name of Issuer)

(Title of Class of Securities)

(CUSIP Number)

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

*Does not include additional shares of uniQure N.V. which Bristol-Myers Squibb Company is obligated to purchase after July 12, 2015 but prior to December 31, 2015 that, together with the 4.9% of shares disclosed above, would result in Bristol-Myers Squibb Company owning 9.9% of uniQure N.V.’s outstanding shares immediately following such acquisition.  See Item 4 for additional information.

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In connection with a Collaboration and License Agreement (the “Collaboration and License Agreement”), dated April 6, 2015,  that provides Bristol-Myers Squibb Company (“BMS”) with exclusive access to uniQure N.V.’s (“uniQure”) gene therapy technology platform for multiple targets for cardiovascular and potentially other diseases, BMS acquired from uniQure on June 12, 2015 1,112,319 ordinary shares, or 4.9% of uniQure’s outstanding ordinary shares immediately following such issuance (the “Initial Closing”).  These shares were acquired pursuant to a Share Subscription Agreement between BMS and uniQure, dated April 6, 2015.  The percentage of ordinary shares reported owned by BMS was calculated using as the denominator 22,700,390 ordinary shares outstanding as of June 12, 2015, which is comprised of 21,588,071 shares that uniQure represented to BMS was outstanding immediately prior to uniQure’s issuance of shares to BMS at the Initial Closing, plus the 1,112,319 shares issued to BMS at the Initial Closing.

After July 12, 2015, but prior to December 31, 2015, BMS is obligated to acquire a number of additional shares that, together with the shares acquired at the Initial Closing, would equal 9.9% of the outstanding shares immediately following such acquisition (the “Second Closing”).  uniQure also has granted BMS two warrants (“Warrant 1” and “Warrant 2”). Pursuant to Warrant 1, BMS may acquire, in its sole discretion, an additional number of shares that, together with the shares acquired at the Initial Closing and Second Closing, would equal 14.9% of uniQure’s outstanding shares immediately after such issuance.  Pursuant to Warrant 2, BMS may acquire, in its sole discretion, an additional number of shares that, together with the shares then owned by BMS, would equal 19.9% of uniQure’s outstanding shares immediately after such issuance.  The exercise of each warrant is conditioned upon the designation by BMS of a certain number of additional collaboration targets and the payment by BMS to uniQure of related fees under the Collaboration and License Agreement.

uniQure and BMS also entered into an investor agreement regarding certain rights and restrictions relating to uniQure’s ordinary shares acquired or to be acquired by BMS, including (i) certain ‘‘standstill’’ restrictions that, subject to certain exceptions, restrict BMS from acquiring shares of uniQure in addition to any shares acquired in the manner described above and from taking certain other actions with respect to uniQure or its shares, its assets or its board of directors; (ii) lock-up restrictions that restrict BMS from selling or disposing of the shares acquired or to be acquired for a certain period without uniQure’s prior consent; and (iii) the requirement that BMS vote all of its shares in favor of all items on the agenda for the relevant general meeting of shareholders of uniQure as proposed on behalf of uniQure, subject to certain exceptions, including BMS’ voting rights relative to certain change of control transactions.  The voting provisions will terminate upon the earlier to occur of (1) the date on which BMS no longer beneficially owns at least 4.9% of the outstanding shares of uniQure, (2) the consummation of a change of control transaction relative to uniQure and (3) the termination by BMS of the Collaboration and License Agreement for breach by uniQure.

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SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: June 22, 2015

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