UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  Schedule 13D

                    Under the Securities Exchange Act of 1934

                                (Amendment No. 2)

                   Integra LifeSciences Holdings Corporation 
                                (Name of Issuer)

                          Common Stock Par Value $.01 
                         (Title of Class of Securities)

                                   457985208 
                                 (CUSIP Number)

                                 Stuart M. Essig
                  c/o Integra LifeSciences Holdings Corporation
                              311 Enterprise Drive
                          Plainsboro, New Jersey 08536

                                 With a copy to:

                                Jonathan B. Levy
                           Lindquist & Vennum P.L.L.P.
                                 4200 IDS Center
                          Minneapolis, Minnesota 55402
                                 (612) 371-5211

                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                January 30, 2006
             (Date of Event Which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) or 13(d)-1(g), check the following
box. [ ]

Note: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
to whom copies are to be sent.

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).





-----------------------
CUSIP No.     457985208
-----------------------
---------- --------------------------------------------------------------------
    1      Names of reporting persons
           S.S. or I.R.S. Identification No. of above persons

           Stuart M. Essig
---------- --------------------------------------------------------------------
    2      Check the appropriate box if a member of a group 
           (see instructions)     (a) [   ]
                                  (b) [   ]
---------- --------------------------------------------------------------------
    3      SEC use only

---------- --------------------------------------------------------------------
    4      Source of funds (see instructions)

           PF
---------- --------------------------------------------------------------------
    5      Check if disclosure of legal proceedings is required pursuant 
           to items 2(d) or 2(e) [   ]

---------- --------------------------------------------------------------------
    6      Citizenship or place of organization

           United States
---------- --------------------------------------------------------------------
Number of           7        Sole voting power

shares                       1,948,022*

beneficially        -------- --------------------------------------------------
                    8        Shared voting power
owned by
                             54,358
each                -------- --------------------------------------------------
                    9        Sole dispositive power
reporting
                             1,948,022*
person with         -------- --------------------------------------------------
                    10       Shared dispositive power

                             54,358
---------- --------------------------------------------------------------------
   11      Aggregate amount beneficially owned by each reporting person

           2,002,380*
---------- --------------------------------------------------------------------
   12      Check box if the aggregate amount in row (11) excludes certain 
           shares  [   ]

           (See instructions)
---------- --------------------------------------------------------------------
   13      Percent of class represented by amount in row (11)

           6.8%
---------- --------------------------------------------------------------------
   14      Type of reporting person (See instructions)

           IN
---------- --------------------------------------------------------------------
* Includes 1,031,943 shares of common stock underlying options to purchase
common stock. Options to purchase 530,360 shares of common stock are exercisable
as of, or within 60 days of, January 30, 2006. Although shares underlying all
options held by Mr. Essig are included in the amounts set forth on lines 7, 9
and 11, Mr. Essig disclaims beneficial ownership of the 501,583 shares of common
stock underlying options not exercisable as of, or within 60 days of, January
30, 2006.






This Amendment No. 2 ("Amendment No. 2") amends and supplements the statement on
Schedule 13D initially filed on November 14, 2005 (the "Original Filing" and, 
as amended, the "Schedule 13D") by Stuart M. Essig with respect to Common Stock,
$.01 par value (the "common stock"), of Integra LifeSciences Holdings 
Corporation (the "Company").  Capitalized terms used and not defined in this
Amendment No. 1 have the meanings set forth in the Schedule 13D.

Item 5.           Interest in Securities of Issuer

                  Item 5 of the Schedule 13D is hereby amended and restated in
                  its entirety as follows:

                  (a) Aggregate number and percentage of class beneficially 
                      owned:

                           As of January 30, 2006, Mr. Essig may be deemed to be
                           the beneficial owner of 2,002,380 shares of common
                           stock. This ownership consists of the following:

                           (i) 916,079 shares of common stock held directly by
                           Mr. Essig;

                           (ii) 54,358 shares of common stock held by the Essig
                           Enright Family Foundation (the "Foundation"), of
                           which Mr. Essig and his wife are two of the three
                           trustees; and

                           (iii) 1,031,943 shares of common stock underlying
                           options to purchase common stock (of which options to
                           purchase 530,360 shares of common stock are
                           exercisable as of, or within 60 days of, January 30,
                           2006).

                           Based on calculations made in accordance with Rule 
                           13d-3(d), Mr. Essig may be deemed the beneficial 
                           owner of 6.8% of the outstanding shares of common 
                           stock. This calculation is based on 28,265,615
                           shares of common stock outstanding as of January 27, 
                           2006.

                           The above calculations include 501,583 shares of 
                           common stock underlying options held by Mr. Essig 
                           that are not exercisable as of, or within 60 days of,
                           January 30, 2006. Mr. Essig disclaims beneficial 
                           ownership of these shares. Excluding these shares, 
                           Mr. Essig would be deemed the beneficial owner of 
                           1,500,797 shares of commons stock (or 5.2% of the 
                           outstanding shares of common stock).


                  (b) Voting and Dispositive Power:

                           Mr. Essig has sole voting and dispositive power over
                           1,948,022 shares that may be deemed to be
                           beneficially owned by him as of January 30, 2006.
                           This consists of the following (i) the 916,079 shares
                           of common stock held directly by Mr. Essig and (ii)
                           1,031,943 shares of common stock underlying options
                           to purchase common stock, of which Mr. Essig
                           disclaims beneficial ownership with respect to
                           501,583 shares of common stock as set forth in Item
                           5(a).

                           Mr. Essig may be deemed to have shared voting and
                           dispositive power over the 54,358 shares of common
                           stock held by the Foundation.



                  (c) Transactions within the past 60 days:

                           On December 30, 2005, Mr. Essig purchased 696 shares
                           of common stock from the Company under the Company's
                           Employee Stock Purchase Plan at a price of $30.14 per
                           share in a transaction exempt under Rule 16b-3 under
                           the Act.

                           Transactions entered into on December 19, 2005 and
                           January 3, 2006 by Mr. Essig were reported on
                           Amendment No. 1 to the Schedule 13D filed on January
                           4, 2006.

                  (d) Right to Direct the Receipt of Dividends: Not applicable.

                  (e) Last Date on Which Reporting Person Ceased to be a 5% 
                      Holder: Not Applicable.

Item 6.           Contracts, Arrangements, Understandings or Relationships with 
                  Respect to Securities of the Issuer.
                  
                  The information under the heading "Sale Plans Under Rule
                  10b5-1" of Item 6 of the Schedule 13D is hereby amended and
                  restated in its entirety as follows:

                  Sale Plans Under Rule 10b5-1

                  Mr. Essig entered into two sales plans pursuant to Rule 10b5-1
                  under the Act with a registered broker-dealer. One plan
                  provided for the sale of 340,000 shares of the 750,000 shares
                  of common stock underlying Restricted Units and issued to Mr.
                  Essig on January 3, 2006. This plan was entered into to enable
                  Mr. Essig to obtain proceeds to cover tax liabilities
                  associated with his receipt of the 750,000 shares of common
                  stock. The other plan provides for the sale of up to 200,000
                  shares of common stock underlying options (and the exercise of
                  the related options) at specified prices. On January 3, 2006,
                  Mr. Essig sold 340,000 shares pursuant to the first Rule
                  10b5-1 plan described above. On January 30, 2006, Mr. Essig
                  terminated the second Rule 105-1 plan described above in its
                  entirety.


                                    Signature

         After reasonable inquiry and to the best of his knowledge and belief,
the undersigned certify that the information set forth in this statement is
true, complete and correct.

Dated:  January 31, 2006


                            Name /s/ Stuart M. Essig 
                                 -------------------