OMB APPROVAL

OMB Number:             3235-0101
Expires:          December 31, 2009
Estimated average burden
hours per response. . . . . . . . . 2.00

SEC USE ONLY

DOCUMENT SEQUENCE NO.

CUSIP NUMBER

WORK LOCATION

1  (a)  NAME OF ISSUER (Please type or print)
         Humana Inc.

(b)  IRS IDENT. NO.
      61-0647538

(c)  S.E.C. FILE NO.
      1-5975

          500 West Main Street                                                                                        Louisville                                KY                          40202

(e)  TELEPHONE

AREA CODE
502

NUMBER
580-1000

2  (a)  NAME OF PERSON FOR WHOSE ACCOUNT THE SECURITIES
         ARE TO BE SOLD

        W. Ann Reynolds, Ph.D.

(b)  IRS IDENT. NO.


      N/A

(c)  RELATIONSHIP TO
      ISSUER
Director

(d)  ADDRESS STREET               CITY         STATE      ZIP CODE

      500 W. Main Street             Louisville       KY           40202

INSTRUCTION:   The person filing this notice should contact the issuer to obtain the I.R.S. identification Number and the S.E.C. File Number

Title of the Class of Securities
To Be Sold

Name and Address of Each Broker Through Whom the Securities Are To Be Offered or Each Market Maker who is Acquiring the Securities

SEC USE ONLY

Number of Shares
or Other Units
To Be Sold
(See Instr. 3 (c))

Aggregate
Market
Value
(See Instr. 3(d)

Number of Shares
or Other Units
Outstanding
(See Instr. 3(e))

Approximate Date of Sale
(See Instr. 3(f))
(MO.  DAY  YR.)

Name of Each
Securities
Exchange
(See instr. 3 g))

Broker-Dealer
File Number

Common

Merrill Lynch
420 N. 20th Street, Suite 2600
Birmingham, AL 35203

5,000

$121,775
based on FMV on
11/21/08 of $24.355

168,708,610
as of 11/21/08

November 25, 2008

NYSE

INSTRUCTIONS:
1.  (a)  Name of Issuer
     (b)  Issuer's I.R.S. Identification Number
     (c)  Issuer's S.E.C. file number, if any
     (d)  Issuer's address, including zip code
     (e)  Issuer's telephone number, including area code

3.  (a)  Title of the class of securities to be sold
     (b)  Name and Address of each broker through whom the securities are intended to be sold
     (c)  Number of shares or other units to be sold (if debt securities, give the aggregate face amount)
     (d)  Aggregate market value of the securities to be sold as of a specified date within 10 days prior to the filing of this notice
     (e)  Number of shares or other units of the class outstanding, or if debt securities the face amount thereof outstanding, as shown
           by the most recent report or statement published by the issuer
     (f)  Approximate date on which the securities are to be sold
     (g)  Name of each securities exchange, if any, on which the securities are intended to be sold

2.  (a)  Name of person for whose account the securities are to be sold
     (b)  Such person's I.R.S. identification number, if such person is an entity
     (c)  Such person's relationship to the issuer (e.g., officer, director, 10%
           stockholder, or member of immediate family of any of the foregoing)
     (d)  Such person's address, including zip code

Potential persons who are to respond to the collection of information contained in this form are not
required to respond unless the form displays a currently valid OMB control number.                       

SEC 1147 (01-07)

TABLE I - SECURITIES TO BE SOLD
Furnish the following information with respect to the acquisition of the securities to be sold
and with respect to the payment of all or any part of the purchase price or other consideration therefor.

Title of
the Class

Date you
Acquired

Nature of Acquisition Transaction

Name of the Person from Whom Acquired
(if gift, also give date donor acquired

Amount of
Securities Acquired

Date of
Payment

Nature of Payment

Common

7/31/07

Stock Option Exercise

Issuer

5,000

7/31/07

Stock

INSTRUCTIONS:

If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

_____________________________________________________________________________________________________________________________________________________________________________

TABLE II - SECURITIES SOLD DURING THE PAST 3 MONTHS (1)
Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

Name and Address of Seller

Title of Securities Sold

Date of Sale

Amount of
Securities Sold(2)

Gross Proceeds

REMARKS:

INSTRUCTIONS:

ATTENTION:

See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.

The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the issuer of the securities to be sold which has not been publicly disclosed.

DATE OF NOTICE

/s/ W. Ann Reynolds, Ph.D.
____________________________________________________________________________
(SIGNATURE)

    ATTENTION:    Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)

SEC 1147 (01/04)