SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   SCHEDULE TO

        TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR SECTION 13(E)(1)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
                                (Name of Issuer)

               INTEGRA LIFESCIENCES HOLDINGS CORPORATION (ISSUER)
 (Name of Filing Person (Identifying Status as Offeror, Issuer or Other Person))

            2 1/2% CONTINGENT CONVERTIBLE SUBORDINATED NOTES DUE 2008
                         (Title of Class of Securities)

                      (CUSIP Nos. 457985AA7 AND 457985AB5)
                      (CUSIP Number of Class of Securities)

                              MAUREEN B. BELLANTONI
              EXECUTIVE VICE PRESIDENT AND CHIEF FINANCIAL OFFICER
                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
                              311 ENTERPRISE DRIVE
                             PLAINSBORO, NEW JERSEY
                                 (609) 275-0500

  (Name, Address and Telephone Number of Person Authorized to Receive Notices
             and Communications on Behalf of the Filing Person(s))

                                    COPY TO:
                              PETER LABONSKI, ESQ.
                              LATHAM & WATKINS LLP
                                885 THIRD AVENUE
                               NEW YORK, NY 10022
                                 (212) 906-1200


                            CALCULATION OF FILING FEE

         Transaction valuation*                         Amount of filing fee
         ----------------------                         --------------------
              $120,000,000                                    $12,840

*    Calculated solely for the purpose of determining the amount of the filing
     fee, based upon the exchange of $120,000,000 aggregate principal amount of
     the Issuer's 2 1/2% Contingent Convertible Subordinated Notes due 2008 in
     exchange for Integra LifeSciences Holdings Corporation's 2 1/2% Contingent
     Convertible Subordinated Notes due 2008.

[ ]  Check box if any part of the fee is offset as provided by Rule 0-11(a)(2)
     and identify the filing with which the offsetting fee was previously paid.
     Identify the previous filing by registration statement number, or the form
     or schedule and the date of its filing.

     Amount Previously Paid:   Not applicable.     Filing party: Not applicable.
     Form or Registration No.: Not applicable.     Date Filed:   Not applicable.

[ ]  Check the box if the filing relates solely to preliminary communications
     made before the commencement of a tender offer.

Check the appropriate boxes below to designate any transactions to which the
statement relates:

     [ ]  third-party tender offer subject to Rule 14d-1

     [X]  issuer tender offer subject to Rule 13e-4

     [ ]  going private transaction subject to Rule 13e-3

     [ ]  amendment to Schedule 13D under Rule 13d-2


Check the following box if the filing is a final amendment reporting the results
of the tender offer [ ]



                This  Schedule  TO relates to the offer by Integra  LifeSciences
Holdings  Corporation,  a Delaware  corporation,  (the "Issuer") (i) to exchange
$1,000 in principal amount of 2 1/2% Contingent  Convertible  Subordinated Notes
due 2008 (the "New Notes") and (ii) a one time cash payment (an "Exchange  Fee")
equal to $2.50 for each $1,000 in principal amount of the Issuer's outstanding 2
1/2%  Contingent  Convertible  Subordinated  Notes due 2008 (the "Old Notes" and
together with the New Notes, the "Notes") that is properly tendered and accepted
for exchange upon the terms and subject to the conditions set forth in the Offer
to Exchange  (this "Offer to Exchange") and in the related Letter of Transmittal
(the "Letter of Transmittal")  attached to this Schedule TO as Exhibit (a)(1)(i)
and Exhibit (a)(1)(ii), respectively. The offer to exchange the Notes (including
the payment of an Exchange  Fee)  pursuant to this Offer to Exchange is referred
to herein as an "Offer." The Offer is not contingent upon the tender or exchange
of any minimum principal amount of Old Notes. The Offer, however, is conditioned
upon satisfaction of certain conditions.

                This  Tender  Offer  Statement  on  Schedule  TO is  intended to
satisfy the reporting  requirements of Rule 13e-4 under the Securities  Exchange
Act of 1934, as amended.

ITEM 1.  SUMMARY TERM SHEET

                The  information  set forth in the Offer to  Exchange  under the
caption  "Summary"  and "The  Offer  to  Exchange"  is  incorporated  herein  by
reference.

ITEM 2.  SUBJECT COMPANY INFORMATION

                (a)     NAME AND  ADDRESS.  The name of the  Issuer  is  Integra
LifeSciences  Holdings  Corporation,   a  Delaware  corporation.   The  Issuer's
principal executive offices are located at 311 Enterprise Drive, Plainsboro, New
Jersey, 08536. The telephone number of the Issuer is (609) 275-0500.

                (b)     SECURITIES.  The securities  that are the subject of the
tender offer are the Old Notes.  The aggregate  principal  amount of outstanding
Old Notes is $120,000,000.

                (c)     TRADING  MARKET AND PRICE.  The Old Notes are not listed
and the New Notes  will not be listed on any  national  securities  exchange  or
included on the NASDAQ Stock Market.  There is no established trading market for
the New Notes.  The Issuer's common stock underlying the New Notes trades on the
Nasdaq Global Select Market under the symbol "IART".  The quarterly high and low
trading  prices for the  underlying  stock is set forth in the Offer to Exchange
under the  heading  "Price  Range of Common  Stock and  Dividend  Policy" and is
incorporated herein by reference.

ITEM 3.  IDENTITY AND BACKGROUND OF FILING PERSON

                (a)     NAME  AND   ADDRESS.   Integra   LifeSciences   Holdings
Corporation is the filing person.  The business  address and telephone number of
the filing person are set forth under Item 2(a) above.  The  executive  officers
and directors of the filing person are: Stuart M. Essig,  Maureen B. Bellantoni,
Gerard S. Carlozzi, John B. Henneman, III, David B. Holtz, Judith O'Grady, Keith
Bradley,  Richard E. Caruso,  Christian S. Schade, James M. Sullivan and Anne M.
VanLent.  The  address of each  executive  officer  and  director is c/o Integra
LifeSciences Holdings Corporation,  311 Enterprise Drive, Plainsboro, New Jersey
08536

ITEM 4.  TERMS OF THE TRANSACTION

                (a)     MATERIAL TERMS.

                (1)     TENDER OFFERS.

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                        (i)-(iii) The  information  set  forth  in the  Offer to
Exchange  under the heading "The Offer to Exchange"  is  incorporated  herein by
reference.

                        (iv)    Not applicable.

                        (v)-(viii) The  information  set  forth in the  Offer to
Exchange  under the hading "The Offer to  Exchange"  is  incorporated  herein by
reference.

                        (ix)    Not applicable.

                        (x)     The  information  in the Offer to Exchange under
the headings "Summary"; "Summary Comparison of the Old Notes and the New Notes";
"The Offer to Exchange" and "Description of New Notes" are  incorporated  herein
by reference.

                        (xi)    Not applicable.

                        (xii)   The  information  in the Offer to Exchange under
the  heading  "Certain  United  States  Federal  Income  Tax   Consequences"  is
incorporated herein by reference.

                (b)     PURCHASES. Not applicable.

ITEM 5.  PAST CONTACTS, TRANSACTIONS, NEGOTIATIONS AND AGREEMENTS

                (e)     AGREEMENTS INVOLVING THE COMPANY'S SECURITIES.  Pursuant
to the terms of a forward sale  contract  entered into with Credit  Suisse First
Boston Capital LLC on December 14, 2004,  Stuart Essig,  the Issuer's  President
and Chief  Executive  Officer,  is obligated  to deliver to Credit  Suisse First
Boston LLC on March 28, 2013 between  264,550 and 500,000 shares of common stock
(or, at the election of Mr. Essig,  the cash  equivalent  of such  shares).  Mr.
Essig  retains  voting power over these  shares  pending the  settlement  of the
forward sale contract.  Pursuant to the terms of a forward sale contract entered
into with Credit  Suisse First Boston  Capital LLC on November 23, 2004,  TRU ST
PARTNERSHIP,  L.P.,  a  Pennsylvania  general  partnership  of which  Richard E.
Caruso, the Issuer's Chairman, is the President of the corporate general partner
("TRU ST"), is obligated to deliver to Credit Suisse First Boston LLC on January
15, 2013 between 322,581 and 600,000 shares of common stock (or, at the election
of TRU ST, the cash equivalent of such shares). TRU ST retains voting power over
these shares pending the settlement of the forward sale contract. The Issuer has
also  granted  Mr.  Essig  registration  rights  requiring  the Issuer to file a
"shelf" registration  statement at Mr. Essig's request that will provide for the
registration  and sale on a continuous  or delayed basis of the shares of common
stock underlying the options and restricted units that he holds.

ITEM 6.  PURPOSE OF THE TRANSACTION AND PLANS OR PROPOSALS

                (a)     PURPOSES.  The  information  set  forth in the  Offer to
Exchange   under  the  headings   "The  Offer  to  Exchange"  and  "Summary"  is
incorporated herein by reference.

                (b)     USE OF SECURITIES  ACQUIRED.  The Old Notes  acquired in
the transaction will be retired.

                (c)     PLANS.  Except as  otherwise  disclosed  in the Offer to
Exchange,  the Issuer does not have any plans,  proposals or  negotiations  that
relate to or would result in: (1) any extraordinary corporate transaction,  such
as a merger,  reorganization or liquidation,  involving the Issuer or any or all
of its subsidiaries;  (2) any purchase, sale or transfer of a material amount of
assets of the Issuer or any of its subsidiaries;  (3) any material change in the
Issuer's present dividend rate or policy, or indebtedness or capitalization; (4)
any change in the Issuer's present board of directors or management,  other than
to change the number or the term of directors or to fill any existing  vacancies
on the board of  directors  or to change  any  material  term of the  employment
contract of any executive officer; (5) any other material change in the Issuer's
corporate structure or business; (6) any class of the Issuer's equity securities
being  delisted  from a  national  securities  exchange;  (7) any  class  of the
Issuer's  equity  securities  becoming  eligible for termination of registration
under Section 12 (g) (4) of the Exchange Act; (8) the suspension of the Issuer's
obligation  to file reports  under  Section 15 (d) of the Exchange  Act; (9) the
acquisition  by  any  person  of  additional  securities  of the  Issuer  or the
disposition  of  securities  of the Issuer;  or (10) any change in the  Issuer's
amended and restated  certificate  of  incorporation,  amended  by-laws or other
governing  instruments  or other actions which could impede the  acquisition  of
control of the Issuer.

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ITEM 7.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION

                (a)     SOURCE OF FUNDS.  The information set forth in the Offer
to Exchange under the caption "Summary" is incorporated herein by reference.  In
connection with the Offer to Exchange,  an Exchange Fee will be paid noteholders
who exchange  their Old Notes for New Notes.  The Exchange Fee will be paid from
cash on hand.

                (b)     CONDITIONS. Not applicable.

                (d)     BORROWED FUNDS. Not applicable.

ITEM 8.  INTEREST IN SECURITIES OF THE SUBJECT COMPANY

                (a)     SECURITIES   OWNERSHIP.   None  of  the  Old  Notes  are
beneficially  owned by the Issuer or any  director,  officer or affiliate of the
Issuer.

                (b)     SECURITIES TRANSACTIONS. None.

ITEM 9.  PERSONS/ASSETS, RETAINED, EMPLOYED, COMPENSATED OR USED

                (a)     SOLICITATION OR RECOMMENDATION. None.

ITEM 10.  FINANCIAL STATEMENTS

                (a)     FINANCIAL INFORMATION.

                (a)(1)  The  information  in  Part  II,  Item 8 of the  Issuer's
Annual Report on Form 10-K for the year ended December 31, 2005 is  incorporated
herein by reference.


                (a)(2)  The  information  in  Part  I,  Item 1 of  the  Issuer's
Quarterly  Report on Form 10-Q for the quarterly period ending on March 31, 2006
is incorporated herein by reference.

                (a)(3)  The information set forth in the Offer to Exchange under
the heading "Price Range of Common Stock and Dividend  Policy--Ratio of Earnings
to Fixed Charges" is incorporated herein by reference.

                (a)(4)  The information set forth in the Offer to Exchange under
the  heading  "Selected   Financial   Information"  is  incorporated  herein  by
reference.

                (b)     PRO FORMA FINANCIAL INFORMATION. None.

                (c)     SUMMARY  INFORMATION.  The  information set forth in the
Offer  to  Exchange  under  the  heading  "Selected  Financial  Information"  is
incorporated herein by reference.


ITEM 11.  ADDITIONAL INFORMATION

                (a)     AGREEMENTS,    REGULATORY    REQUIREMENTS    AND   LEGAL
PROCEEDINGS. None.

                (b)     OTHER MATERIAL INFORMATION. None.

ITEM 12.  EXHIBITS.

(a)(1)(i)       Offer to Exchange, dated July 17, 2006.

(a)(1)(ii)      Letter of Transmittal.

(a)(1)(iii)     Notice of Guaranteed Delivery.

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(a)(1)(iv)      Letter to Brokers,  Dealers,  Commercial Banks,  Trust Companies
                and Other Nominees.

(a)(1)(v)       Letter to Clients for use by Brokers, Dealers, Commercial Banks,
                Trust Companies and Other Nominees.

(a)(5)(i)       Press Release, dated July 17, 2006.

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SIGNATURE

                After due inquiry and to the best of my knowledge and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.

Dated:  July 17, 2006                  INTEGRA LIFESCIENCES HOLDINGS CORPORATION




                                       By: /s/ Maureen B. Bellantoni
                                          -------------------------------------
                                           Name:  Maureen B. Bellantoni
                                           Title: Executive Vice President
                                                  and Chief Financial Officer

                                       6



EXHIBIT INDEX

EXHIBIT
NUMBER          DESCRIPTION
-------         -----------

(a)(1)(i)       Offer to Exchange, dated July 17, 2006.

(a)(1)(ii)      Letter of Transmittal.

(a)(1)(iii)     Notice of Guaranteed Delivery.

(a)(1)(iv)      Letter to Brokers,  Dealers,  Commercial Banks,  Trust Companies
                and Other Nominees.

(a)(1)(v)       Letter to Clients for use by Brokers, Dealers, Commercial Banks,
                Trust Companies and Other Nominees.

(a)(5)(i)       Press Release, dated July 17, 2006.



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