Rationally Designed PMN310 Targets Toxic Amyloid-Beta Oligomers Selectively and Efficiently
ProMIS Neurosciences, a pioneering biotech firm specializing in antibody therapeutics targeting toxic misfolded proteins linked to neurodegenerative conditions such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and multiple system atrophy (MSA), showcased new preclinical data at the Alzheimer’s Association International Conference (AAIC) 2023. This data emphasizes the potential benefits of their leading AD candidate, PMN310.
PMN310’s Selective Action on Amyloid-Beta Oligomers
The highlighted findings revealed that PMN310 could more selectively target toxic amyloid-beta oligomers compared to other amyloid-beta-oriented antibodies synthesized using synthetic oligomers. PMN310 is a humanized IgG1 antibody, focusing on these toxic amyloid-beta oligomers (AβO).
ProMIS’s proprietary computational modeling platform generated PMN310, using an algorithm to identify specific targets in a toxic protein species to avoid cross-reactivity with other protein forms. Such a highly selective AβO-targeted response potentially leads to enhanced clinical activity and improved safety profile, outpacing less selective approaches.
A Milestone for ProMIS – FDA Approval and Phase 1a Clinical Trial
In May 2023, the U.S. Food and Drug Administration (FDA) approved ProMIS’s Investigational New Drug (IND) application for PMN310 for AD treatment. Following this clearance, the company plans to launch a Phase 1a clinical trial to assess the pharmacokinetics, safety, and tolerability of PMN310 in healthy adult volunteers.
Vaccine Candidate for Alzheimer’s Disease Prevention
ProMIS is also making strides in preventative measures for AD. Their rationally designed vaccine candidate has shown a robust and sustained antibody response in preclinical evaluations. This response is primarily focused on pathogenic amyloid-beta oligomers, which further supports the company’s efforts to generate a highly selective AβO-targeted response.
Achieving Potent AD Prevention
The vaccine consists of an AβO conformational B cell peptide epitope linked to a carrier protein to provide T cell help. This combination has elicited a robust and enduring antibody response. Moreover, the serum antibodies were selective for AβO with no detectable binding to monomers or plaque, reducing the risk of Aβ-related imaging abnormalities (ARIA). This promising data backs ProMIS’s approach in designing an AD prevention vaccine that offers sustained anti-disease activity with fewer doses compared to chronic antibody treatment.
With the advancements of PMN310 and the AD prevention vaccine, ProMIS Neurosciences is poised to revolutionize the fight against Alzheimer’s disease. By leveraging computational modeling platforms and focusing on highly selective AβO-targeted responses, the company is setting new benchmarks in neurodegenerative disease research and therapy.
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