UNIONDALE, NY / ACCESS Newswire / July 29, 2025 / Marquis Who's Who honors Terry Guido for success in preclinical research and development, studying Alzheimer's Disease. As manager of the anatomy and pathology lab at Elan Pharmaceuticals, her career reflected a dedication to research and data analysis. For over 20 years at Elan Pharmaceuticals and four years at Janssen Alzheimer Immunotherapy, concurrently, this top professional emerged as a leading figure in managing the delicate intersection of biological data and operational efficiency.

Foundation in Scientific Inquiry

Ms. Guido managed the anatomy and pathology lab for Elan Pharmaceuticals for nearly 21 years. In this capacity, she oversaw the daily operations of the imaging and histology facilities, coordinated with stakeholders, and supervised team members. With attention to detail and commitment to scientific integrity, she helped maintain the integrity of Elan's reliability of its research and data analysis.

This dedication stems from a long history of meticulous research. Ms. Guido began her career at Athena Neurosciences in 1992. While there, she sharpened her skills in scientific inquiry until Athena merged with Elan Pharmaceuticals in 1996. Within this company, she rose through the ranks from research associate to manager of anatomy and pathology. She developed optimal methods for antigen retrieval for multiple immunofluorescent labeling and quantification, making it possible to visualize several cellular structures and their spatial relationships. During her tenure, she worked with her lab to characterize the first animal model of Alzheimer's-like pathology, and the first ever in the world to see amyloid beta plaques prevented and removed by immunization. This led to the landmark scientific breakthrough that led to the development of the first Alzheimer's vaccine.

From 2009 to 2012, Ms. Guido held the role of associate manager at Janssen Alzheimer Immunotherapy. Her research approach went beyond industry standards. While handling research operations for the dual roles, keeping data secure and separate between Elan and Janssen, she continued her work at the bench and was tasked to develop more sophisticated immunohistochemical staining paradigms, leading to much more robust and revealing data.

Insights Into Advanced Research

Ms. Guido attributes her success to relentless curiosity and her incredible mentor, Dr. Dora Games. Pathology often progresses more slowly than other research areas. It requires meticulous data gathering and verification. With persistence, she helped characterize a transgenic mouse model with AD-like pathology and the development of amyloid plaque and dystrophic neurites with age. It required diligent attention to the generation and quantification of thousands of mouse brain sections for amyloid and neuritic burden, vascular elements, and inflammatory cells with Alzheimer 's-like pathology. This work helped set the groundwork for treating the disease.

Additionally, Ms. Guido used the multiplex labeling paradigm she had developed and determined the temporal relationship of treatment-related amyloid clearance, microhemorrhage, smooth muscle, and elastic layer recovery during the acute phases of vascular amyloid clearance. As a result, she helped demonstrate complex pathology during antibody treatment in transgenic mouse model. The results of her findings advanced her scientific understanding of vascular pathology.

A Passion for Science Education

Ms. Guido has garnered recognition for her achievements. For example, she received an Award of Excellence from Elan Pharmaceuticals and a Janssen Encore Award. Meanwhile, she continues to make contributions to the scientific community.

Plans are underway to extend Ms. Guido's philanthropic efforts to middle schools. She aims to continue supplying science classrooms with lab equipment and learning materials with the assistance of her college colleague and science teacher, Jan Mathews. With a bachelor's degree and a master's degree in avian science from the University of California Davis, Ms. Guido views education as a vehicle for change.

In the forthcoming phase of her career, Ms. Guido is focused on publishing a book that translates her laboratory experience into accessible insights for families supporting loved ones with Alzheimer's Disease. The book aims to enhance understanding of the condition and provide practical strategies for the care of family members. This represents a significant shift from her extensive background in preclinical research on Alzheimer's Disease. "I evolved with the science," she notes. "I push forward." Ms. Guido views writing as an opportunity to impart her expertise and offer guidance to the next generation of scientists.

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SOURCE: Marquis Who's Who